Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22456647 | 0.99 | BIRC2 (0.35) | OPRM1OPRK1BIRC2PRCPHDAC3 | |
| SCHEMBL26996818 | 0.93 | OPRM1 (0.37) | OPRM1OPRK1BIRC2PRCPSIGMAR1 | |
| SCHEMBL26996825 | 0.92 | BIRC2 (0.37) | OPRM1OPRK1BIRC2PRCPSIGMAR1 | |
| SCHEMBL26996981 | 0.87 | HDAC3 (0.38) | OPRM1BIRC2PRCPHDAC3HDAC4 | |
| SCHEMBL22808526 | 0.87 | HDAC3 (0.38) | OPRM1BIRC2PRCPHDAC3HDAC4 | |
| SCHEMBL22872971 | 0.83 | CHRNB2 (0.36) | OPRM1OPRK1PRCPHDAC3HDAC4 | |
| SCHEMBL26269491 | 0.83 | CRHR1 (0.38) | OPRM1OPRK1PRCPSIGMAR1 | |
| SCHEMBL23978901 | 0.82 | CRHR1 (0.40) | OPRM1OPRK1PRCPSIGMAR1 | |
| SCHEMBL18289331 | 0.82 | NTRK1 (0.39) | OPRM1OPRK1PRCPSIGMAR1CHRNB2 | |
| SCHEMBL24304296 | 0.81 | IDO1 (0.35) | OPRM1BIRC2PRCPHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10870663-B2 | Compounds useful in HIV therapy | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10870663-B2 | Compounds useful in HIV therapy | CCR5, SLC11A2, CD4 | OPRM1 2164/4885OPRK1 1588/4885BIRC2 2782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.