Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19563654 | 0.89 | SCN8A (0.47) | SCN8ASCN10AFFAR1MAPTLMNA | |
| SCHEMBL19563711 | 0.88 | ALDH1A3 (0.44) | SCN8ASCN10AFFAR1MAPTLMNA | |
| SCHEMBL5988928 | 0.84 | SCN8A (0.45) | SCN8ASCN10AMAPTLMNAKMT2A | |
| SCHEMBL18570392 | 0.83 | SCN8A (0.46) | SCN8ASCN10AFFAR1MAPTLMNA | |
| SCHEMBL18570362 | 0.83 | HTR2A (0.52) | SCN8ASCN10AMAPTLMNAKMT2A | |
| SCHEMBL4613870 | 0.82 | LMNA (0.57) | SCN8ASCN10AFFAR1MAPTLMNA | |
| SCHEMBL22809693 | 0.82 | SCN8A (0.48) | SCN8ASCN10AFFAR1MAPTLMNA | |
| SCHEMBL18570742 | 0.76 | SCN8A (0.52) | SCN8ASCN10AMAPTLMNAKMT2A | |
| SCHEMBL18570880 | 0.76 | SCN10A (0.50) | SCN8ASCN10AMAPTL3MBTL1POLB | |
| SCHEMBL957598 | 0.75 | ALDH1A1 (0.41) | SCN8ASCN10AMAPTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |