SCHEMBL22809762

SCHEMBL22809762

COc1ccc(Oc2ccc(C)cc2C=O)cc1F

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 3/20 0.46
ALDH1A1 P00352 5/20 0.44
LMNA P02545 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
KDM4E B2RXH2 1/20 0.41
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
TUBB1 Q9H4B7 4/20 0.40
AR P10275 2/20 0.40
ACHE P22303 1/20 0.40
BACE1 P56817 2/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
TTR P02766 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19563671 0.86 ERN1 (0.46) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL22809674 0.84 SCN8A (0.47) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL19563576 0.82 SCN8A (0.49) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL19563648 0.82 SCN8A (0.47) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL9868048 0.81 NPSR1 (0.53) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL419596 0.79 ALDH1A1 (0.57) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL25642257 0.77 TUBB1 (0.51) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL5321372 0.76 NPSR1 (0.47) ALDH1A1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL22809675 0.76 SCN8A (0.50) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL21129706 0.75 LMNA (0.62) ERN1ALDH1A1LMNACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3239134-B1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMA (US) 2020-12-23 EP disclosed