Sugi Predict

Sugi Predict / Compounds / SCHEMBL95806

SCHEMBL95806

SCHEMBL95806

COc1ccc(Cl)cc1C=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ERN1 O75460 4/20 0.58
▸ ALDH1A1 P00352 6/20 0.56
▸ HPGD P15428 3/20 0.56
▸ KDM4E B2RXH2 4/20 0.55
▸ TDP1 Q9NUW8 2/20 0.55
▸ TSHR P16473 2/20 0.55
▸ PKM P14618 1/20 0.47
▸ TUBB1 Q9H4B7 1/20 0.46
▸ TRPV4 Q9HBA0 1/20 0.46
▸ PRKDC P78527 1/20 0.46
▸ CYP1A2 P05177 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ LMNA P02545 2/20 0.44
▸ MAPT P10636 2/20 0.44
▸ ATM Q13315 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29956352 1.00 ERN1 (0.58) ERN1ALDH1A1HPGDKDM4ETDP1
SCHEMBL1570210 0.84 ALDH1A1 (0.63) ERN1ALDH1A1HPGDKDM4ETDP1
SCHEMBL2419953 0.83 ALDH1A1 (0.61) ERN1ALDH1A1HPGDKDM4ETDP1
SCHEMBL10401197 0.82 KDM4E (0.49) ERN1ALDH1A1HPGDKDM4ETSHR
SCHEMBL19563669 0.81 SCN8A (0.47) ERN1ALDH1A1HPGDKDM4ETDP1
SCHEMBL4600075 0.81 ERN1 (0.54) ERN1ALDH1A1HPGDKDM4ETDP1
SCHEMBL4039108 0.80 ALDH1A1 (0.48) ERN1ALDH1A1HPGDKDM4ETDP1
SCHEMBL30304244 0.80 ALDH1A1 (0.54) ERN1ALDH1A1HPGDKDM4ETSHR
SCHEMBL29189167 0.80 ALDH1A1 (0.54) ERN1ALDH1A1HPGDKDM4ETSHR
SCHEMBL19563667 0.80 ALDH1A1 (0.50) ERN1ALDH1A1HPGDKDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6388081-B1 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries LION BIOSCIENCE AG (DE) 2002-05-14 — — US claimed
US-6262269-B1 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries TREGA BIOSCIENCES, INC. 2001-07-17 — — US claimed
EP-0977989-A1 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 2000-02-09 — — EP claimed
WO-1998034115-A1 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 — — WO claimed
EP-4725942-A1 COMPOUNDS ACTIVE ON CYCLIN D1 PATHWAY AND THEIR USE Sibylla Biotech S.p.A. (IT) 2026-04-15 — — EP disclosed
EP-4605409-A2 CYCLIN INHIBITORS Circle Pharma, Inc. (US) 2025-08-27 — — EP disclosed
US-12221406-B2 Compounds as NLRP3 inflammasome inhibitors and compositions and uses thereof VIRGINIA COMMONWEALTH UNIVERSITY (US) 2025-02-11 — — US disclosed
US-20240218021-A1 CYCLIN INHIBITORS CIRCLE PHARMA, INC. 2024-07-04 — — US disclosed
US-20240150364-A1 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS GENENTECH, INC. (US) 2024-05-09 — — US disclosed
WO-2024086814-A2 CYCLIN INHIBITORS CIRCLE PHARMA, INC. (US) 2024-04-25 — — WO disclosed
US-11952365-B2 Anti-viral compounds ALIGOS THERAPEUTICS, INC. (US) 2024-04-09 — — US disclosed
US-20240043400-A1 Octahydroisoquinolinyl Derivatives UCB Biopharma SRL (BE) 2024-02-08 — — US disclosed
EP-0117035-A2 Aldose reductase inhibiting 5-(2-alkoxyphenyl)thiazolidinediones PFIZER INC. (US) 1984-08-29 — — EP disclosed
US-4448971-A Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1984-05-15 — — US disclosed
US-4407811-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1983-10-04 — — US disclosed
US-4399296-A TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES PFIZER INC. (US) 1983-08-16 — — US disclosed
US-4367234-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1983-01-04 — — US disclosed
EP-0003056-B1 N-SUBSTITUTED OMEGA-AMINOALKANOYL-OMEGA-AMINOALKANECARBOXYLIC ACIDS, THEIR APPLICATION AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THESE COMPOUNDS Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1982-08-18 — — EP disclosed
US-4250183-A GASTOINTESTINAL DISORDERS; DISEASES OF THE PANCREAS, GALL BLADDER, AND LIVER BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1981-02-10 — — US disclosed
EP-0003056-A1 N-substituted omega-aminoalkanoyl-omega-aminoalkanecarboxylic acids, their application and process for their preparation, and medicines containing these compounds Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1979-07-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11952365-B2 Anti-viral compounds EIF2AK2, ZC3HAV1, HAVCR2 ERN1 282/4885ALDH1A1 2039/4885HPGD 4005/4885
US-20240218021-A1 CYCLIN INHIBITORS CCNI, CCNC, CDK2 ERN1 874/4885ALDH1A1 2597/4885HPGD 439/4885
US-20240150364-A1 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS JAK1, JAK2, JAK3 ERN1 1089/4885ALDH1A1 1375/4885HPGD 1731/4885
US-20240043400-A1 Octahydroisoquinolinyl Derivatives OPRD1, OPRK1, OPRL1 ERN1 3248/4885ALDH1A1 1187/4885HPGD 922/4885
US-12221406-B2 Compounds as NLRP3 inflammasome inhibitors and compositions and uses thereof NLRP3, PYCARD, NLRP1 ERN1 1421/4885ALDH1A1 4070/4885HPGD 1968/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.