SCHEMBL22820117

SCHEMBL22820117

O=C(Nc1ccccc1)c1cccc(C(=O)Nc2ccccc2Cl)c1F

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.64
HPGD P15428 1/20 0.64
CYP2C19 P33261 1/20 0.64
RXFP1 Q9HBX9 1/20 0.54
SMO Q99835 4/20 0.54
KCNK3 O14649 1/20 0.54
KCNK9 Q9NPC2 1/20 0.54
MEN1 O00255 7/20 0.52
KMT2A Q03164 7/20 0.52
MAPT P10636 4/20 0.52
TDP1 Q9NUW8 4/20 0.52
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
MAPK1 P28482 2/20 0.52
KDM4E B2RXH2 1/20 0.52
POLB P06746 1/20 0.52
GAA P10253 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
PTGES O14684 1/20 0.50
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22819974 0.92 CYP1A2 (0.60) CYP1A2HPGDCYP2C19RXFP1SMO
SCHEMBL22820075 0.85 HTT (0.61) HPGDMEN1KMT2ATDP1NPC1
SCHEMBL22820172 0.82 HPGD (0.64) CYP1A2HPGDCYP2C19RXFP1KCNK3
SCHEMBL22820171 0.82 KMT2A (0.60) HPGDRXFP1MEN1KMT2AMAPT
SCHEMBL22819966 0.81 ALDH1A1 (0.70) HPGDMEN1KMT2ATDP1NPC1
SCHEMBL27879746 0.81 MEN1 (0.62) HPGDRXFP1SMOKCNK3KCNK9
SCHEMBL31680566 0.81 CYP1A2 (0.89) CYP1A2HPGDCYP2C19MEN1KMT2A
SCHEMBL22819969 0.80 KMT2A (0.60) MEN1KMT2AMAPTTDP1NPC1
SCHEMBL22819939 0.80 LMNA (0.70) HPGDKCNK3KCNK9MEN1KMT2A
SCHEMBL22820182 0.79 KMT2A (0.66) RXFP1KCNK3KCNK9MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020255425-A1 ANTI-HBV AGENT 国立研究開発法人理化学研究所 2020-12-24 WO disclosed