Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914412 | 0.90 | USP30 (0.46) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL22820577 | 0.90 | USP30 (0.46) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL13740383 | 0.85 | LMNA (0.48) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL26987927 | 0.84 | USP30 (0.47) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL13154983 | 0.84 | KMT2A (0.45) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL890187 | 0.84 | KMT2A (0.45) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL14757730 | 0.84 | KMT2A (0.45) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL31290628 | 0.84 | USP30 (0.47) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL38652154 | 0.83 | ALDH1A1 (0.44) | USP30UCHL1KMT2ANR1H2NR1H3 | |
| SCHEMBL29747883 | 0.81 | RIPK1 (0.46) | UCHL1KMT2ANPSR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020255022-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND AMINOPYRIDINE DERIVATIVES AS HPK1 INHIBITORS | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-24 | — | — | WO | disclosed |