Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914412 | 1.00 | USP30 (0.46) | USP30KMT2AUCHL1NPSR1MAPT | |
| SCHEMBL22820439 | 0.90 | USP30 (0.46) | USP30KMT2AUCHL1NPSR1MAPT | |
| SCHEMBL28946618 | 0.85 | TSHR (0.45) | KMT2AUCHL1NPSR1MAPTNPC1 | |
| SCHEMBL28946619 | 0.85 | TSHR (0.45) | KMT2AUCHL1NPSR1MAPTNPC1 | |
| SCHEMBL30078355 | 0.85 | TSHR (0.45) | KMT2AUCHL1NPSR1MAPTNPC1 | |
| SCHEMBL22820517 | 0.85 | AAK1 (0.37) | USP30KMT2AUCHL1MAPTNR1H2 | |
| SCHEMBL22820737 | 0.85 | PIK3CD (0.44) | USP30KMT2AUCHL1NR1H2NR1H3 | |
| SCHEMBL22820604 | 0.83 | CCR2 (0.37) | USP30KMT2AUCHL1NR1H2NR1H3 | |
| SCHEMBL13740383 | 0.82 | LMNA (0.48) | USP30KMT2AUCHL1NPSR1MAPT | |
| SCHEMBL24479083 | 0.81 | USP30 (0.42) | USP30KMT2AUCHL1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177458-A1 | HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-09 | — | — | US | disclosed |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-02 | — | — | US | disclosed |
| WO-2020255022-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND AMINOPYRIDINE DERIVATIVES AS HPK1 INHIBITORS | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | PCK1, PGK1, PDXK | USP30 2293/4885KMT2A 2847/4885UCHL1 4438/4885 |
| US-20220177458-A1 | HPK1 INHIBITORS | PGK1, PCK1, PDXK | USP30 1783/4885KMT2A 2493/4885UCHL1 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.