Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 4/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655715 | 0.78 | MCHR1 (1.00) | MCHR1NCF1 | |
| SCHEMBL4701200 | 0.78 | NPC1 (0.69) | MCHR1NPC1PDE10AMIF | |
| SCHEMBL19603062 | 0.78 | MCHR1 (0.67) | MCHR1NPC1PDE10AMIF | |
| SCHEMBL8889339 | 0.77 | MCHR1 (0.57) | MCHR1PARP1NPC1PDE10AMIF | |
| SCHEMBL20660519 | 0.77 | MCHR1 (0.54) | MCHR1PARP1NPC1PDE10AMIF | |
| SCHEMBL22901625 | 0.73 | PDE10A (0.56) | MCHR1NPC1PDE10AMIF | |
| SCHEMBL4432906 | 0.72 | MAP4K4 (0.54) | MCHR1PARP1NPC1MIF | |
| SCHEMBL10996108 | 0.72 | PARP1 (0.69) | MCHR1PARP1NPC1PDE10A | |
| SCHEMBL2820875 | 0.71 | FEN1 (0.57) | PDE10A | |
| SCHEMBL483733 | 0.71 | RAB9A (0.64) | NPC1NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344559-B2 | PI3KGAMMA inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-31 | — | — | US | claimed |
| US-20200405730-A1 | PI3KGAMMA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-12-31 | — | — | US | claimed |
| WO-2020264120-A1 | PI3KGAMMA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-12-30 | — | — | WO | claimed |
| US-11344559-B2 | PI3KGAMMA inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-31 | — | — | US | disclosed |
| US-11344559-B2 | PI3KGAMMA inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-31 | — | — | US | disclosed |
| US-20200405730-A1 | PI3KGAMMA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-12-31 | — | — | US | disclosed |
| US-20200405730-A1 | PI3KGAMMA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-12-31 | — | — | US | disclosed |
| WO-2020264120-A1 | PI3KGAMMA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020264120-A1 | PI3KGAMMA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200405730-A1 | PI3KGAMMA INHIBITORS | PIK3R5, PI4KB, PIK3R4 | MCHR1 4691/4885PARP1 1133/4885NPC1 3286/4885 |
| US-11344559-B2 | PI3KGAMMA inhibitors | PIK3R5, PI4KB, PIK3R4 | MCHR1 4691/4885PARP1 1133/4885NPC1 3286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.