Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25552341 | 0.89 | CYP2C19 (0.47) | LTKCDK8MAP2K1ROCK1NTRK3 | |
| SCHEMBL22968687 | 0.83 | HDAC8 (0.40) | HDAC8LTKCDK8MAP2K1ROCK1 | |
| SCHEMBL22837015 | 0.83 | TTR (0.42) | LTKCDK8MAP2K1ROCK1NTRK3 | |
| SCHEMBL22837049 | 0.82 | CYP2C19 (0.49) | CYP2C19CYP1A2ALDH1A1MEN1POLB | |
| SCHEMBL27831377 | 0.81 | NFKB1 (0.35) | HDAC8LTKCDK8MAP2K1ROCK1 | |
| SCHEMBL22837047 | 0.80 | THRA (0.43) | LTKCDK8MAP2K1ROCK1NTRK3 | |
| SCHEMBL13543254 | 0.79 | CYP1A2 (0.46) | CYP2C19CYP1A2MEN1MAPTCYP2C9 | |
| SCHEMBL22837025 | 0.76 | CNR2 (0.45) | — | |
| SCHEMBL22837004 | 0.75 | L3MBTL1 (0.49) | ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL22837003 | 0.75 | KMT2A (0.53) | MAPTMAPK1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667667-B2 | Steroid derivative FXR agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-10875888-B2 | Steroid derivative FXR agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667667-B2 | Steroid derivative FXR agonist | NR1H4, SLC10A1, FXR1 | HDAC8 1344/4885LTK 1091/4885CDK8 3153/4885 |
| US-10875888-B2 | Steroid derivative FXR agonist | NR1H4, SLC10A1, FXR1 | HDAC8 1344/4885LTK 1091/4885CDK8 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.