Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13875976 | 0.83 | PROKR1 (0.44) | PROKR1MAPTACACB | |
| SCHEMBL13875972 | 0.83 | KCNK3 (0.48) | KCNK3KCNK9NR2E1CTSAPROKR1 | |
| SCHEMBL13875980 | 0.79 | EPHX2 (0.50) | EPHX2NR2E1MAPTGSK3B | |
| SCHEMBL22837124 | 0.78 | MAPT (0.46) | EPHX2IDO1MAPT | |
| SCHEMBL13876023 | 0.77 | MAOB (0.46) | MAPTACACB | |
| SCHEMBL22837057 | 0.77 | LNPEP (0.37) | LTKCDK8MAP2K1ROCK1NTRK3 | |
| SCHEMBL13875983 | 0.76 | SMN1; SMN2 (0.48) | EPHX2TSHRKDM1AMAPTGSK3B | |
| SCHEMBL22837003 | 0.76 | KMT2A (0.53) | MAPT | |
| SCHEMBL13876008 | 0.73 | LOXL2 (0.41) | — | |
| SCHEMBL13876011 | 0.73 | KDM4E (0.42) | KCNK3KCNK9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667667-B2 | Steroid derivative FXR agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11667667-B2 | Steroid derivative FXR agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-20210040140-A1 | Steroid Derivative FXR Agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-02-11 | — | — | US | disclosed |
| US-10875888-B2 | Steroid derivative FXR agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667667-B2 | Steroid derivative FXR agonist | NR1H4, SLC10A1, FXR1 | KCNK3 3740/4885KCNK9 3574/4885LTK 1091/4885 |
| US-20210040140-A1 | Steroid Derivative FXR Agonist | NR1H4, SLC10A1, FXR1 | KCNK3 3740/4885KCNK9 3574/4885LTK 1091/4885 |
| US-10875888-B2 | Steroid derivative FXR agonist | NR1H4, SLC10A1, FXR1 | KCNK3 3740/4885KCNK9 3574/4885LTK 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.