Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 11/20 | 1.00 |
| ▸ | CYP26B1 | Q9NR63 | 8/20 | 1.00 |
| ▸ | RARA | P10276 | 5/20 | 0.51 |
| ▸ | RARB | P10826 | 5/20 | 0.51 |
| ▸ | RARG | P13631 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | BLVRB | P30043 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445083 | 0.83 | CYP26A1 (0.73) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL22838045 | 0.80 | CYP26A1 (0.67) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL22838114 | 0.80 | CYP26A1 (1.00) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL22838088 | 0.78 | CYP26A1 (1.00) | CYP26A1CYP26B1MEN1KMT2AALDH1A1 | |
| SCHEMBL5538662 | 0.76 | RXRA (0.64) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL6890868 | 0.75 | RXRA (0.79) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL1074782 | 0.75 | RXRA (0.62) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL5534931 | 0.74 | RXRA (0.72) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL6147894 | 0.73 | RXRA (0.64) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL6890777 | 0.73 | CYP2C9 (0.60) | CYP26A1CYP26B1RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11364220-B2 | Compounds and methods for inhibiting CPY26 enzymes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-06-21 | — | — | US | disclosed |
| US-20210220326-A1 | Compounds and Methods for Inhibiting CPY26 Enzymes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-07-22 | — | — | US | disclosed |
| US-10874634-B2 | Compounds and methods for inhibiting CYP26 enzymes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874634-B2 | Compounds and methods for inhibiting CYP26 enzymes | CYP26B1, CYP2A6, CYP26A1 | CYP26A1 3/4885CYP26B1 1/4885RARA 16/4885 |
| US-11364220-B2 | Compounds and methods for inhibiting CPY26 enzymes | CYP2A6, CYP27A1, CYP26B1 | CYP26A1 4/4885CYP26B1 3/4885RARA 40/4885 |
| US-20210220326-A1 | Compounds and Methods for Inhibiting CPY26 Enzymes | CYP2A6, CYP27A1, CYP26B1 | CYP26A1 4/4885CYP26B1 3/4885RARA 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.