SCHEMBL2284176

SCHEMBL2284176

COOc1c(-c2ccc(O)cc2)oc2cc(O)cc(O)c2c1=O

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.81
CYP2D6 P10635 4/20 0.81
POLH Q9Y253 4/20 0.81
KDM4E B2RXH2 3/20 0.81
POLB P06746 2/20 0.81
APEX1 P27695 2/20 0.81
RECQL P46063 2/20 0.81
MCL1 Q07820 1/20 0.81
ABCB1 P08183 3/20 0.67
MEN1 O00255 2/20 0.66
MAPT P10636 2/20 0.66
KMT2A Q03164 2/20 0.66
HSD17B10 Q99714 2/20 0.66
MMP1 P03956 1/20 0.66
GAA P10253 1/20 0.66
HTT P42858 1/20 0.66
BLM P54132 1/20 0.66
RPS6KA3 P51812 3/20 0.65
CYP1A1 P04798 2/20 0.65
CYP1A2 P05177 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17102291 0.90 POLH (0.82) CYP3A4CYP2D6POLHKDM4EPOLB
Isokaempferide SCHEMBL1628023 0.90 POLH (1.00) CYP3A4CYP2D6POLHKDM4EPOLB
Isokaempferide SCHEMBL29721227 0.90 POLH (1.00) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL27093588 0.88 POLH (0.67) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL28664318 0.88 TUBB4A (0.75) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL18923490 0.84 POLH (0.76) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL30627918 0.84 CYP3A4 (0.75) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL21376116 0.84 POLH (0.75) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL21375998 0.84 POLH (0.75) CYP3A4CYP2D6POLHKDM4EPOLB
SCHEMBL30627917 0.84 CYP3A4 (0.75) CYP3A4CYP2D6POLHKDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110195138-A1 Anti-inflammatory cranberry flavonol extract preparations RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2011-08-11 US disclosed
US-20070292539-A1 Anti-inflammatory cranberry flavonol extract preparations VORSA NICHOLI 2007-12-20 US disclosed
US-7270837-B2 free of anthocyanins and proanthocyanidins; treatment of inflammatory disorders, particularly irritation of the urinary tract due to both bacterial and non-bacterial causes RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2007-09-18 US disclosed
US-20060088610-A1 Anti-inflammatory cranberry flavonol extract preparations RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2006-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070292539-A1 Anti-inflammatory cranberry flavonol extract preparations LGALS3, FUT6, GALNT6 CYP3A4 1687/4885CYP2D6 461/4885POLH 2773/4885
US-20060088610-A1 Anti-inflammatory cranberry flavonol extract preparations LGALS3, FUT6, GALNT6 CYP3A4 1687/4885CYP2D6 461/4885POLH 2773/4885
US-20110195138-A1 Anti-inflammatory cranberry flavonol extract preparations LGALS3, FUT6, GALNT6 CYP3A4 1687/4885CYP2D6 461/4885POLH 2773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.