Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 3/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | DCPS | Q96C86 | 3/20 | 0.32 |
| ▸ | NQO2 | P16083 | 3/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | DUT | P33316 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | G6PD | P11413 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22844249 | 0.82 | HTT (0.45) | TLR8POLBLMNA | |
| SCHEMBL2031432 | 0.68 | CXCR4 (0.62) | TLR8POLBLMNANPC1RAB9A | |
| SCHEMBL22844246 | 0.68 | DRD3 (0.37) | NPC1RAB9A | |
| SCHEMBL22844183 | 0.67 | CSF1R (0.41) | TLR8CSF1RPOLB | |
| SCHEMBL22844182 | 0.66 | CXCR4 (0.63) | TLR8POLBMAPT | |
| SCHEMBL22844210 | 0.65 | DUT (0.34) | DUT | |
| SCHEMBL6530152 | 0.64 | CYP2D6 (0.50) | POLBLMNAMAPT | |
| SCHEMBL6606918 | 0.64 | LMNA (0.41) | LMNANPC1MAPTPKMRAB9A | |
| SCHEMBL22571857 | 0.63 | STING1 (0.41) | NPC1RAB9A | |
| SCHEMBL5459067 | 0.63 | PRMT5 (0.60) | CASRTLR8DCPSNQO2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020260252-A1 | NEW MACROCYCLIC COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-12-30 | — | — | WO | disclosed |