Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.39 |
| ▸ | BCKDK | O14874 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 4/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18701941 | 0.80 | BCKDK (0.38) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL18701613 | 0.74 | BCKDK (0.44) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL18701665 | 0.74 | BCKDK (0.41) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL22917717 | 0.73 | BCKDK (0.45) | GPR35BCKDKDAOMCL1STING1 | |
| SCHEMBL18701551 | 0.72 | BCKDK (0.36) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL22917718 | 0.72 | GPR35 (0.49) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL18701625 | 0.71 | DAO (0.39) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL18701692 | 0.71 | BCKDK (0.46) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL20893768 | 0.71 | ALDH1A1 (0.42) | GPR35BCKDKALDH1A1HPGDTSHR | |
| SCHEMBL21858819 | 0.71 | GPR35 (0.39) | GPR35BCKDKALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542270-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-11542270-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-11059833-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-11059833-B2 | BCKDK inhibitors | PFIZER INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20210087204-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-03-25 | — | — | US | disclosed |
| US-20210087204-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-03-25 | — | — | US | disclosed |
| US-20210024536-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-01-28 | — | — | US | disclosed |
| US-20210024536-A1 | BCKDK INHIBITORS | PFIZER INC. (US) | 2021-01-28 | — | — | US | disclosed |
| WO-2020261205-A1 | THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID COMPOUNDS HAVING BCKDK INHIBITING ACTIVITY | PFIZER INC. (US) | 2020-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087204-A1 | BCKDK INHIBITORS | BCKDK, PDK4, PDK3 | GPR35 3710/4885BCKDK 1/4885ALDH1A1 272/4885 |
| US-11059833-B2 | BCKDK inhibitors | BCKDK, PDK4, PDK3 | GPR35 3710/4885BCKDK 1/4885ALDH1A1 272/4885 |
| US-11542270-B2 | BCKDK inhibitors | BCKDK, PDK4, PDK3 | GPR35 3710/4885BCKDK 1/4885ALDH1A1 272/4885 |
| US-20210024536-A1 | BCKDK INHIBITORS | BCKDK, PDK4, PDK3 | GPR35 3710/4885BCKDK 1/4885ALDH1A1 272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.