Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845486 | 0.85 | GNRHR (0.36) | GNRHRHTR2CPOLBHSP90AA1HSP90AB1 | |
| SCHEMBL22845408 | 0.84 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL22845219 | 0.83 | HTR2C (0.39) | GNRHRHTR2CUSP2ALDH1A1CYP1A2 | |
| SCHEMBL22717381 | 0.77 | GNRHR (0.37) | GNRHRHTR2CHSP90AA1HSP90AB1HTR6 | |
| SCHEMBL22845210 | 0.77 | ALDH1A1 (0.42) | GNRHRHTR2CPOLBSMN1; SMN2USP2 | |
| SCHEMBL24469835 | 0.77 | CRBN (0.39) | HTR2CHSP90AA1HSP90AB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22845398 | 0.77 | GNRHR (0.40) | GNRHRHTR2CHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL24470067 | 0.74 | HTR2C (0.35) | HTR2CCYP3A4SIGMAR1 | |
| SCHEMBL24469920 | 0.71 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1 | |
| SCHEMBL24469782 | 0.71 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | GNRHR 2198/4885HTR2C 467/4885POLB 3198/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | GNRHR 2198/4885HTR2C 467/4885POLB 3198/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | GNRHR 2198/4885HTR2C 467/4885POLB 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.