Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845205 | 0.84 | GNRHR (0.38) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL22845219 | 0.77 | HTR2C (0.39) | ALDH1A1HPGDRAB9AHIF1AHSD17B10 | |
| SCHEMBL22845486 | 0.77 | GNRHR (0.36) | ALDH1A1HPGDTSHRHTT | |
| SCHEMBL22845409 | 0.75 | TSHR (0.40) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL22845403 | 0.74 | TP53 (0.45) | ALDH1A1MAPTKMT2A | |
| SCHEMBL22845210 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HPGDHIF1ASMN1; SMN2HSD17B10 | |
| SCHEMBL24469835 | 0.73 | CRBN (0.39) | ALDH1A1SMN1; SMN2TSHRCASP1 | |
| SCHEMBL22845404 | 0.73 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPTKDM4ERAB9A | |
| SCHEMBL22717381 | 0.69 | GNRHR (0.37) | KDM4ETSHRKMT2A | |
| SCHEMBL22845398 | 0.69 | GNRHR (0.40) | ALDH1A1MAPTKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | ALDH1A1 648/4885HPGD 1777/4885MAPT 651/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | ALDH1A1 648/4885HPGD 1777/4885MAPT 651/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | ALDH1A1 648/4885HPGD 1777/4885MAPT 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.