Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845487 | 0.82 | HTR2C (0.38) | GNRHRHTR2CNPC1RAB9AHTR2A | |
| SCHEMBL22717381 | 0.80 | GNRHR (0.37) | GNRHRHTR2CHTR6HTR2AHTR2B | |
| SCHEMBL22845205 | 0.77 | GNRHR (0.38) | GNRHRALDH1A1HTR2CHTR6CYP3A4 | |
| SCHEMBL22845486 | 0.72 | GNRHR (0.36) | GNRHRALDH1A1HTR2CHTR6SIGMAR1 | |
| SCHEMBL22845219 | 0.70 | HTR2C (0.39) | GNRHRALDH1A1HTR2CNPC1RAB9A | |
| SCHEMBL22845408 | 0.69 | ALDH1A1 (0.43) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL22845396 | 0.69 | GNRHR (0.44) | GNRHRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL22845397 | 0.65 | KDM4E (0.43) | ALDH1A1CYP2C9CYP2C19CYP3A4KDM4E | |
| SCHEMBL22845436 | 0.64 | HTR2C (0.36) | HTR2CHTR2AHTR2BMCHR1KDM4E | |
| SCHEMBL22845308 | 0.63 | DPP4 (0.52) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | GNRHR 2198/4885ALDH1A1 648/4885HTR2C 467/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | GNRHR 2198/4885ALDH1A1 648/4885HTR2C 467/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | GNRHR 2198/4885ALDH1A1 648/4885HTR2C 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.