Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845233 | 0.90 | ALDH1A1 (0.37) | LMNAALOX15USP2GAAALDH1A1 | |
| SCHEMBL22845412 | 0.89 | MAPT (0.41) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL22845206 | 0.89 | POLB (0.41) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL22845429 | 0.85 | ALDH1A1 (0.43) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL22845438 | 0.81 | GNRHR (0.39) | LMNAALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL22845325 | 0.81 | MAPT (0.41) | LMNAGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL22845211 | 0.80 | MAPT (0.44) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL22845323 | 0.80 | MTHFD2 (0.34) | ALDH1A1HDAC6HTTKDR | |
| SCHEMBL22845448 | 0.80 | MAPT (0.39) | LMNAALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL22845215 | 0.80 | KMT2A (0.46) | LMNAUSP2GAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | LMNA 1680/4885ALOX15 2143/4885USP2 4405/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | LMNA 1680/4885ALOX15 2143/4885USP2 4405/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | LMNA 1680/4885ALOX15 2143/4885USP2 4405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.