Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845203 | 0.82 | KDM5A (0.42) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18044696 | 0.75 | ALDH1A1 (0.50) | ALDH1A1RAB9AHPGDKDM4ERECQL | |
| SCHEMBL13131093 | 0.75 | ALDH1A1 (0.50) | ALDH1A1RAB9AHPGDKDM4EHIF1A | |
| SCHEMBL22845485 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPK1TSHRALOX15 | |
| SCHEMBL11605011 | 0.75 | KDM4E (0.65) | ALDH1A1RAB9AHPGDKDM4EHIF1A | |
| SCHEMBL22845222 | 0.74 | REN (0.41) | ALDH1A1RAB9ANPC1 | |
| SCHEMBL30924896 | 0.73 | KDM4E (0.76) | ALDH1A1RAB9AHPGDKDM4EHIF1A | |
| SCHEMBL12756114 | 0.73 | KDM4E (0.76) | ALDH1A1RAB9AHPGDKDM4EHIF1A | |
| SCHEMBL22845408 | 0.73 | ALDH1A1 (0.43) | ALDH1A1RAB9AHPGDKDM4EHIF1A | |
| SCHEMBL12756115 | 0.71 | KDM4E (0.48) | ALDH1A1RAB9AHPGDKDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | ALDH1A1 648/4885RAB9A 488/4885HPGD 1777/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | ALDH1A1 648/4885RAB9A 488/4885HPGD 1777/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | ALDH1A1 648/4885RAB9A 488/4885HPGD 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.