Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 3/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294602 | 1.00 | TAS2R14 (0.49) | TAS2R14AKR1C3AKR1C2MPOMEN1 | |
| SCHEMBL30294355 | 0.86 | MEN1 (0.47) | TAS2R14AKR1C3AKR1C2MPOMEN1 | |
| SCHEMBL22852834 | 0.86 | MEN1 (0.47) | TAS2R14AKR1C3AKR1C2MPOMEN1 | |
| SCHEMBL22853396 | 0.84 | ALDH1A1 (0.47) | TAS2R14ALDH1A1 | |
| SCHEMBL30294743 | 0.84 | ALDH1A1 (0.47) | TAS2R14ALDH1A1 | |
| SCHEMBL22852845 | 0.84 | KDM4E (0.46) | TAS2R14AKR1C3AKR1C2MPOMEN1 | |
| SCHEMBL30294776 | 0.84 | KDM4E (0.46) | TAS2R14AKR1C3AKR1C2MPOMEN1 | |
| SCHEMBL22852801 | 0.84 | FTO (0.48) | MEN1KMT2AMAPK1FABP4PLK1 | |
| SCHEMBL30294752 | 0.84 | FTO (0.48) | MEN1KMT2AMAPK1FABP4PLK1 | |
| SCHEMBL22852851 | 0.82 | PBRM1 (0.56) | AKR1C3MEN1KMT2AMAPK1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |