Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294847 | 1.00 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HPGDRAB9ASORT1 | |
| SCHEMBL30294412 | 0.90 | SORT1 (0.54) | ALDH1A1SORT1MEN1KMT2ALMNA | |
| SCHEMBL22853174 | 0.90 | SORT1 (0.54) | ALDH1A1SORT1MEN1KMT2ALMNA | |
| SCHEMBL22853368 | 0.89 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDRAB9ASORT1 | |
| SCHEMBL30294399 | 0.89 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDRAB9ASORT1 | |
| SCHEMBL22833733 | 0.87 | MKNK2 (0.47) | ALDH1A1SMN1; SMN2RAB9ASORT1MPO | |
| SCHEMBL29382196 | 0.87 | MKNK2 (0.47) | ALDH1A1SMN1; SMN2RAB9ASORT1MPO | |
| SCHEMBL22833312 | 0.83 | DHODH (0.56) | SORT1DHODHTAS2R14HDAC6 | |
| SCHEMBL29383420 | 0.83 | DHODH (0.56) | SORT1DHODHTAS2R14HDAC6 | |
| SCHEMBL22853093 | 0.82 | DHODH (0.47) | ALDH1A1SORT1MPOMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |