Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22855639 | 0.96 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10ROCK2 | |
| SCHEMBL22855472 | 0.85 | PRMT5 (0.47) | ROCK2MAPT | |
| SCHEMBL22855250 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10MAPK8 | |
| SCHEMBL22855681 | 0.82 | PRMT5 (0.44) | ROCK2MAPT | |
| SCHEMBL28502959 | 0.76 | PRMT5 (0.38) | ROCK2MAPT | |
| SCHEMBL22855632 | 0.75 | ALDH1A1 (0.53) | ALDH1A1KDM4EPTPN1NPC1RAB9A | |
| SCHEMBL23175679 | 0.73 | SMYD3 (0.56) | ROCK2ROCK1NAMPTMAPK8MAPK10 | |
| SCHEMBL22855214 | 0.73 | GFER (0.38) | ROCK2PTPN1HDAC1 | |
| SCHEMBL23240775 | 0.72 | PRMT5 (0.53) | MAPT | |
| SCHEMBL22855638 | 0.72 | KDM4E (0.35) | ALDH1A1KDM4EHPGDHSD17B10CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112125886-B | Tricyclic compounds as PRMT5 inhibitors and application thereof | 南京圣和药物研发有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2020259478-A1 | TRICYCLIC COMPOUND AS PRMT5 INHIBITOR AND APPLICATION THEREOF | 南京圣和药物研发有限公司 | 2020-12-30 | — | — | WO | disclosed |