Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22855472 | 0.86 | PRMT5 (0.47) | MAPTCRBNPIM1PIM2JAK1 | |
| SCHEMBL28502959 | 0.85 | PRMT5 (0.38) | MAPTDDB1CRBN | |
| SCHEMBL22855681 | 0.82 | PRMT5 (0.44) | MAPTHTTCRBNPIM1PIM2 | |
| SCHEMBL22855214 | 0.80 | GFER (0.38) | PTPN1JAK1 | |
| SCHEMBL22855475 | 0.75 | ALDH1A1 (0.45) | ALDH1A1NPC1RAB9AMAPTPTPN2 | |
| SCHEMBL10269535 | 0.74 | ALDH1A1 (0.63) | ALDH1A1NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL22855213 | 0.74 | CDC7 (0.33) | DDB1CRBNPIM1PIM2 | |
| SCHEMBL1704497 | 0.74 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL28811700 | 0.73 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL29992015 | 0.73 | ALDH1A1 (0.69) | ALDH1A1NPC1RAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112125886-B | Tricyclic compounds as PRMT5 inhibitors and application thereof | 南京圣和药物研发有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2020259478-A1 | TRICYCLIC COMPOUND AS PRMT5 INHIBITOR AND APPLICATION THEREOF | 南京圣和药物研发有限公司 | 2020-12-30 | — | — | WO | disclosed |