Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 7/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21023599 | 0.86 | GNAO1 (0.38) | GNAO1GNAI3GNAI1PKMHTT | |
| SCHEMBL13597080 | 0.81 | GNAI3 (0.53) | GNAO1GNAI3GNAI1PKMHTT | |
| SCHEMBL22562145 | 0.80 | GNAI3 (0.55) | GNAO1GNAI3GNAI1PKMHTT | |
| SCHEMBL18761634 | 0.80 | GNAI3 (0.55) | GNAO1GNAI3GNAI1PKMHTT | |
| SCHEMBL22150235 | 0.79 | AKR1C3 (0.37) | GNAO1GNAI3GNAI1 | |
| SCHEMBL21078068 | 0.78 | LSS (0.50) | GNAO1GNAI3GNAI1PKMHTT | |
| SCHEMBL22756299 | 0.78 | EPHX2 (0.35) | GNAO1GNAI3GNAI1POLB | |
| SCHEMBL27793328 | 0.78 | GNAI3 (0.53) | GNAO1GNAI3GNAI1PKMHTT | |
| SCHEMBL22302356 | 0.77 | GNAO1 (0.46) | GNAO1GNAI3GNAI1 | |
| SCHEMBL5810827 | 0.76 | GNAI3 (0.51) | GNAO1GNAI3GNAI1PKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |