Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 3/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22856502 | 0.86 | GNAO1 (0.45) | GNAO1GNAI3GNAI1POLBHPGD | |
| SCHEMBL22150235 | 0.83 | AKR1C3 (0.37) | GNAO1GNAI3GNAI1 | |
| SCHEMBL22756299 | 0.83 | EPHX2 (0.35) | GNAO1GNAI3GNAI1POLB | |
| SCHEMBL12641 | 0.79 | GNAI3 (0.45) | GNAO1GNAI3GNAI1POLBHPGD | |
| SCHEMBL22526178 | 0.79 | HSD17B10 (0.33) | — | |
| SCHEMBL772816 | 0.78 | GNAI3 (0.44) | GNAO1GNAI3GNAI1POLBHPGD | |
| SCHEMBL22269816 | 0.77 | CYP1A2 (0.35) | GNAO1GNAI3GNAI1POLBHPGD | |
| SCHEMBL24258280 | 0.77 | NCF1 (0.52) | — | |
| SCHEMBL24508731 | 0.76 | GPR119 (0.32) | — | |
| SCHEMBL12016032 | 0.75 | GNAI3 (0.45) | GNAO1GNAI3GNAI1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080087-B1 | N-SUBSTITUTED PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORP (US) | 2019-05-22 | — | — | EP | disclosed |