SCHEMBL22859632

SCHEMBL22859632

Cc1cc(OCc2c(S(C)(=O)=O)ccc(C(=O)C3=C(O)CCCC3=O)c2Cl)n(-c2ccccc2)n1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM5A P29375 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
RORC P51449 7/20 0.33
NTRK1 P04629 1/20 0.33
F10 P00742 3/20 0.32
ALOX5 P09917 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
ALDH1A1 P00352 2/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
BDKRB2 P30411 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22859731 0.88 RORC (0.32) RORCBDKRB2
SCHEMBL29736590 0.88 RORC (0.32) RORCBDKRB2
SCHEMBL22859642 0.87 RORC (0.33) RORCALDH1A1ATML3MBTL1BDKRB2
SCHEMBL22859631 0.86 CRHR1 (0.31) RORC
SCHEMBL22859699 0.84 RORC (0.34) RORC
SCHEMBL22859548 0.79 ALDH1A1 (0.36) RORCALDH1A1
SCHEMBL22859556 0.79
SCHEMBL22859704 0.79
SCHEMBL28523331 0.77 RORC (0.33) RORCBDKRB2
SCHEMBL23061233 0.74 SMN1; SMN2 (0.36) MAPTALDH1A1L3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021000736-A1 SUBSTITUTED BENZOYL-PYRAZOLE COMPOUND, AND APPLICATION THEREOF IN AGRICULTURE 东莞市东阳光农药研发有限公司 2021-01-07 WO disclosed