Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15716545 | 0.91 | BRD4 (0.44) | BRD4SMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL15716909 | 0.90 | BRD4 (0.42) | BRD4SMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL15716821 | 0.82 | KDM4E (0.45) | BRD4SMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL15716555 | 0.81 | KCNH2 (0.41) | BRD4SMN1; SMN2KDM4EHTTADORA2A | |
| SCHEMBL15716820 | 0.80 | KDM4E (0.39) | BRD4SMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL15716757 | 0.80 | KCNH2 (0.41) | BRD4SMN1; SMN2KDM4ETDP1HTT | |
| SCHEMBL18598914 | 0.79 | ALDH1A1 (0.47) | BRD4KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL22860002 | 0.77 | PKM (0.34) | BRD4SMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL15716634 | 0.77 | L3MBTL1 (0.40) | BRD4SMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL15717004 | 0.77 | MCL1 (0.38) | BRD4KDM4ETDP1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114286818-B | Heterocyclic compounds as BET inhibitors | 诺维逊生物股份有限公司 | 2024-09-20 | — | — | CN | disclosed |
| US-20230339964-A1 | HETEROCYCLIC COMPOUNDS AS BET INHIBITORS | NUVATION BIO INC (US) | 2023-10-26 | — | — | US | disclosed |
| US-20230339964-A1 | HETEROCYCLIC COMPOUNDS AS BET INHIBITORS | NUVATION BIO INC (US) | 2023-10-26 | — | — | US | disclosed |
| EP-3997070-A1 | HETEROCYCLIC COMPOUNDS AS BET INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| CN-114286818-A | Heterocyclic compounds as BET inhibitors | 诺维逊生物股份有限公司 | 2022-04-05 | — | — | CN | disclosed |
| WO-2021003310-A1 | HETEROCYCLIC COMPOUNDS AS BET INHIBITORS | NUVATION BIO INC. (US) | 2021-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339964-A1 | HETEROCYCLIC COMPOUNDS AS BET INHIBITORS | BET1, BRD4, BRD3 | BRD4 2/4885SMN1; SMN2 2600/4885KDM4E 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.