Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE6A | P16499 | 1/20 | 0.37 |
| ▸ | PDE6B | P35913 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2286831 | 0.84 | TLR8 (0.39) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2292965 | 0.84 | TLR8 (0.39) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL4110513 | 0.84 | DYRK1A (0.43) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL4111040 | 0.82 | DYRK1A (0.41) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL8012476 | 0.82 | PDE10A (0.42) | PDE10AALDH1A1TP53KDM4EHPGD | |
| SCHEMBL4117124 | 0.81 | TLR8 (0.38) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL4110190 | 0.80 | ALDH1A1 (0.43) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2289585 | 0.80 | TLR8 (0.36) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2286837 | 0.80 | TLR8 (0.36) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2285504 | 0.80 | TLR8 (0.36) | TLR8DYRK1ACDK9ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247571-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INCORPORATED | 2009-10-01 | — | — | US | claimed |
| US-7998976-B2 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20090247571-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INCORPORATED | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247571-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | TLR8 4865/4885DYRK1A 3439/4885CDK9 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.