Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GRK6 | P43250 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 3/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4111040 | 0.81 | DYRK1A (0.41) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL4105471 | 0.81 | GRK6 (0.48) | TLR8ALDH1A1HTTKDM4EGRK6 | |
| SCHEMBL2286012 | 0.80 | TLR8 (0.43) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2286831 | 0.79 | TLR8 (0.39) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2292965 | 0.79 | TLR8 (0.39) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL4110513 | 0.79 | DYRK1A (0.43) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL2286837 | 0.78 | TLR8 (0.36) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL977397 | 0.77 | TLR8 (0.33) | TLR8ALDH1A1KDM4EGLAGAA | |
| SCHEMBL4117124 | 0.77 | TLR8 (0.38) | TLR8DYRK1ACDK9ALDH1A1HTT | |
| SCHEMBL4110190 | 0.76 | ALDH1A1 (0.43) | TLR8DYRK1ACDK9ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998976-B2 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. (US) | 2011-08-16 | — | — | US | claimed |
| US-20090247571-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INCORPORATED | 2009-10-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247571-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | TLR8 4865/4885DYRK1A 3439/4885CDK9 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.