Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.48 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861327 | 0.87 | NR4A2 (0.53) | SLC6A3SLC6A4ROCK2ROCK1CYP1A2 | |
| SCHEMBL21359504 | 0.86 | ACMSD (0.54) | SLC6A3SLC6A2SLC6A4CLK2HIPK1 | |
| SCHEMBL22861388 | 0.85 | ROCK2 (0.48) | SLC6A3SLC6A2SLC6A4ROCK2ROCK1 | |
| SCHEMBL21359320 | 0.84 | MIF (0.52) | SLC6A3SLC6A2SLC6A4ALPLROCK2 | |
| SCHEMBL22861263 | 0.81 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4ALPLROCK2 | |
| SCHEMBL2458568 | 0.80 | AKT2 (0.59) | CLK2HIPK1DYRK2HIPK2HIPK3 | |
| SCHEMBL24743461 | 0.79 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4ALPLROCK2 | |
| SCHEMBL30831223 | 0.79 | SLC6A3 (0.74) | SLC6A3SLC6A2SLC6A4ALPLROCK2 | |
| SCHEMBL16683936 | 0.79 | SLC6A3 (1.00) | SLC6A3SLC6A2SLC6A4ALPLROCK2 | |
| SCHEMBL21359389 | 0.78 | SLC6A3 (0.72) | SLC6A3SLC6A2SLC6A4ALPLROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2023-02-23 | — | — | US | disclosed |
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2021-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | SLC6A3 1938/4885SLC6A2 2898/4885SLC6A4 2605/4885 |
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | SLC6A3 1791/4885SLC6A2 2762/4885SLC6A4 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.