Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24704109 | 0.92 | BACE1 (0.38) | TP53RXFP1MAPK14TRIM24ADORA2A | |
| SCHEMBL29490284 | 0.84 | MAPK14 (0.42) | RXFP1MAPK14TRIM24SMN1; SMN2POLB | |
| SCHEMBL22862432 | 0.84 | MAPK14 (0.42) | RXFP1MAPK14TRIM24SMN1; SMN2POLB | |
| SCHEMBL22862944 | 0.81 | MAPK14 (0.38) | TP53MAPK14TRIM24SMN1; SMN2POLB | |
| SCHEMBL22862559 | 0.80 | THRB (0.40) | TP53RXFP1TRIM24SMN1; SMN2POLB | |
| SCHEMBL29490282 | 0.80 | THRB (0.40) | TP53RXFP1TRIM24SMN1; SMN2POLB | |
| SCHEMBL29490287 | 0.75 | POLB (0.45) | RXFP1MAPK14SMN1; SMN2POLBGLA | |
| SCHEMBL22862548 | 0.75 | POLB (0.45) | RXFP1MAPK14SMN1; SMN2POLBGLA | |
| SCHEMBL22862915 | 0.73 | SMN1; SMN2 (0.33) | TRIM24SMN1; SMN2POLBGLAHTT | |
| SCHEMBL22862640 | 0.73 | SMN1; SMN2 (0.41) | TP53TRIM24SMN1; SMN2POLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021002986-A2 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-01-07 | — | — | WO | disclosed |