Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.37 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | SDHB | P21912 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862776 | 0.92 | TP53 (0.36) | ADORA2ATP53RXFP1SMN1; SMN2HTT | |
| SCHEMBL29490284 | 0.85 | MAPK14 (0.42) | RXFP1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL22862432 | 0.85 | MAPK14 (0.42) | RXFP1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL22862944 | 0.81 | MAPK14 (0.38) | TP53SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL22862559 | 0.81 | THRB (0.40) | TP53RXFP1SMN1; SMN2LMNATSHR | |
| SCHEMBL29490282 | 0.81 | THRB (0.40) | TP53RXFP1SMN1; SMN2LMNATSHR | |
| SCHEMBL29490287 | 0.76 | POLB (0.45) | RXFP1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL22862548 | 0.76 | POLB (0.45) | RXFP1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL22862915 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNATSHRHTTTRIM24 | |
| SCHEMBL22862994 | 0.73 | KDM4E (0.37) | TP53SMN1; SMN2TSHRMAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | BAX, TMBIM6, BCL2 | BACE1 282/4885ADORA2A 4518/4885TP53 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.