Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PDE1A | P54750 | 2/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862432 | 1.00 | MAPK14 (0.42) | MAPK14SMN1; SMN2ADORA2BRXFP1RAD52 | |
| SCHEMBL22862944 | 0.88 | MAPK14 (0.38) | MAPK14SMN1; SMN2ALDH1A1PKMTRIM24 | |
| SCHEMBL29490287 | 0.86 | POLB (0.45) | MAPK14SMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL22862548 | 0.86 | POLB (0.45) | MAPK14SMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL24704109 | 0.85 | BACE1 (0.38) | MAPK14SMN1; SMN2RXFP1RAD52TRIM24 | |
| SCHEMBL29490282 | 0.85 | THRB (0.40) | SMN1; SMN2RXFP1ALDH1A1TRIM24POLB | |
| SCHEMBL22862559 | 0.85 | THRB (0.40) | SMN1; SMN2RXFP1ALDH1A1TRIM24POLB | |
| SCHEMBL22862776 | 0.84 | TP53 (0.36) | MAPK14SMN1; SMN2RXFP1RAD52TRIM24 | |
| SCHEMBL22862993 | 0.82 | SIGMAR1 (0.42) | SMN1; SMN2RAD52ALDH1A1LMNAHSD17B10 | |
| SCHEMBL22862463 | 0.82 | CYP11B1 (0.44) | SMN1; SMN2RAD52ALDH1A1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |