SCHEMBL22864282

SCHEMBL22864282

C=Cc1nccc2c1cnn2COCC[Si](C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F2RL1 P55085 1/20 0.32
MAPT P10636 1/20 0.32
DGAT1 O75907 2/20 0.31
ATR Q13535 1/20 0.31
ATRIP Q8WXE1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29661952 1.00 F2RL1 (0.32) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL29966986 0.82 DGAT1 (0.35) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL30720732 0.81 DGAT1 (0.37) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL15667485 0.81 MAPT (0.35) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL29662049 0.81 MAPT (0.35) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL25049222 0.81 DGAT1 (0.33) F2RL1DGAT1ATRATRIP
SCHEMBL30595148 0.80 MAPT (0.34) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL20745940 0.80 MAPT (0.34) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL20746046 0.79 MAPT (0.34) F2RL1MAPTDGAT1ATRATRIP
SCHEMBL19780125 0.78 DGAT1 (0.32) F2RL1MAPTDGAT1ATRATRIP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220315534-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS, INC. 2022-10-06 US disclosed
WO-2021003161-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS, INC. (US) 2021-01-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220315534-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME ADRB2, ADRB1, ADRA2C F2RL1 1354/4885MAPT 2805/4885DGAT1 2468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.