Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10954922 | 0.86 | POLB (0.63) | POLBL3MBTL1EPHX2SCN5ANR1H4 | |
| SCHEMBL11179136 | 0.78 | GAA (0.58) | POLBL3MBTL1GAAGSK3AGSK3B | |
| SCHEMBL10955104 | 0.76 | POLB (0.53) | POLBL3MBTL1GSK3AGSK3BEPHX2 | |
| SCHEMBL8185171 | 0.76 | L3MBTL1 (0.72) | POLBL3MBTL1SCN5ANR1H4MAPT | |
| SCHEMBL11083823 | 0.75 | GSK3A (0.54) | GAAGSK3AGSK3BEPHX2NR1H4 | |
| SCHEMBL9472940 | 0.75 | ATM (0.57) | POLBGAAGSK3AGSK3BMAPT | |
| SCHEMBL19454370 | 0.73 | POLB (0.57) | POLBL3MBTL1GAAEPHX2NR1H4 | |
| SCHEMBL8721198 | 0.73 | POLB (0.49) | POLBL3MBTL1EPHX2SCN5AMAPT | |
| SCHEMBL8718833 | 0.73 | POLB (0.56) | POLBL3MBTL1SCN5AMAPTNOTUM | |
| SCHEMBL254957 | 0.72 | MAPT (0.56) | L3MBTL1GAAEPHX2MAPTPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530250-B2 | Tyrosine-specific functionalized insulin and insulin analogs | MERCK SHARP & DOHME LLC (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210002345-A1 | TYROSINE-SPECIFIC FUNCTIONALIZED INSULIN AND INSULIN ANALOGS | MERCK SHARP & DOHME CORP. (US) | 2021-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002345-A1 | TYROSINE-SPECIFIC FUNCTIONALIZED INSULIN AND INSULIN ANALOGS | IRS1, IGF1R, INSR | POLB 4035/4885L3MBTL1 4167/4885GAA 496/4885 |
| US-11530250-B2 | Tyrosine-specific functionalized insulin and insulin analogs | IRS1, IGF1R, INSR | POLB 4035/4885L3MBTL1 4167/4885GAA 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.