SCHEMBL2286780

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2286768	0.88	TDP1 (0.52)	TDP1MAPTSLC40A1TP53HTT
	SCHEMBL5838972	0.81	GRM5 (0.38)	TDP1MAPTSLC40A1TP53KMT2A
	SCHEMBL31490195	0.79	PSMD14 (0.55)	TDP1MAPTSLC40A1TP53HTT
	SCHEMBL84502	0.79	PSMD14 (0.55)	TDP1MAPTSLC40A1TP53HTT
	SCHEMBL379216	0.79	GLO1 (0.59)	TDP1MAPTSLC40A1TP53HTT
	SCHEMBL21778151	0.79	GABRA1 (0.38)	TDP1MAPTSLC40A1TP53GLO1
	SCHEMBL21248111	0.79	SLC40A1 (0.45)	TDP1MAPTSLC40A1TP53GLO1
	SCHEMBL2283401	0.79	KDR (0.56)	TDP1MAPTSLC40A1HTTGLO1
	SCHEMBL13337941	0.76	MEN1 (0.56)	TDP1MAPTSLC40A1TP53HTT
	SCHEMBL28283795	0.76	MAPT (0.67)	TDP1MAPTTP53HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.