Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505324 | 0.84 | ALDH1A1 (0.59) | SRD5A2ALDH1A1MAPTTHRB | |
| SCHEMBL15559816 | 0.83 | ALDH1A1 (0.41) | SRD5A2ALDH1A1LMNATHRATHRB | |
| SCHEMBL27988584 | 0.83 | PLA2G10 (0.52) | ALDH1A1MAPTEPHX2NR1H4 | |
| SCHEMBL18103219 | 0.83 | KMT2A (0.59) | LMNAMAPTHPGDTHRATHRB | |
| SCHEMBL7670360 | 0.80 | ESR1 (0.38) | ALDH1A1ESR1ESR2ABL1 | |
| SCHEMBL18290661 | 0.79 | MAPT (0.48) | ALDH1A1LMNAMAPTHTTTHRA | |
| SCHEMBL11858297 | 0.78 | CYP1A2 (0.49) | ALDH1A1LMNAHPGDHTT | |
| SCHEMBL850747 | 0.78 | LOXL2 (0.59) | ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL1825537 | 0.78 | ALDH1A1 (0.41) | SRD5A2ALDH1A1THRATHRBABL1 | |
| SCHEMBL18286033 | 0.78 | KDM4E (0.43) | ALDH1A1LMNATHRATHRBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |