Sugi Predict

Sugi Predict / Compounds / SCHEMBL1505324

SCHEMBL1505324

SCHEMBL1505324

O=C(O)c1ccc(CC(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.59
▸ SRD5A2 P31213 4/20 0.53
▸ TP53 P04637 1/20 0.52
▸ TSHR P16473 1/20 0.52
▸ PTPN1 P18031 1/20 0.47
▸ RXRA P19793 2/20 0.46
▸ RXRB P28702 2/20 0.46
▸ RXRG P48443 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ NR4A2 P43354 1/20 0.44
▸ CA12 O43570 1/20 0.44
▸ CA1 P00915 1/20 0.44
▸ CA2 P00918 1/20 0.44
▸ CA3 P07451 1/20 0.44
▸ TYR P14679 1/20 0.44
▸ DRD1 P21728 1/20 0.44
▸ CA4 P22748 1/20 0.44
▸ CA6 P23280 1/20 0.44
▸ CA5A P35218 1/20 0.44
▸ CA7 P43166 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22868058 0.84 SRD5A2 (0.50) ALDH1A1SRD5A2MAPTTHRB
SCHEMBL5495495 0.83 ALDH1A1 (0.55) ALDH1A1SRD5A2TP53TSHRRXRA
SCHEMBL15559816 0.81 ALDH1A1 (0.41) ALDH1A1SRD5A2PTPN1KMT2ACA1
SCHEMBL27988584 0.81 PLA2G10 (0.52) ALDH1A1TSHRKMT2ACA1CA2
SCHEMBL18103219 0.81 KMT2A (0.59) KMT2AMAPTTHRBSMN1; SMN2L3MBTL1
SCHEMBL1825537 0.80 ALDH1A1 (0.41) ALDH1A1SRD5A2PTPN1RXRARXRB
SCHEMBL14089940 0.79 ALDH1A1 (0.56) ALDH1A1SRD5A2TP53TSHRRXRA
SCHEMBL28212525 0.78 TPMT (0.43) ALDH1A1SRD5A2TP53TSHRRXRA
SCHEMBL4679096 0.78 THRB (0.61) ALDH1A1SRD5A2TP53TSHRRXRA
SCHEMBL9815262 0.78 CA2 (0.56) ALDH1A1TSHRRXRARXRBRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108997325-B Aryl bithiazole compound and application thereof 浙江工业大学 2020-08-04 — — CN claimed
US-20260022116-A1 IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF SANOFI-AVENTIS RECHERCHE & DÉVELOPPEMENT (FR) 2026-01-22 — — US disclosed
US-20250388604-A1 Compounds and Their Use as PDE4 Activators MIRONID LIMITED (GB) 2025-12-25 — — US disclosed
EP-4572762-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2025-06-25 — — EP disclosed
WO-2024038128-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS MIRONID LIMITED (GB) 2024-02-22 — — WO disclosed
CN-108997325-B Aryl bithiazole compound and application thereof 浙江工业大学 2020-08-04 — — CN disclosed
WO-2019195775-A1 TOLPERISONE ANALOGS AND METHODS OF USE FLEX PHARMA, INC. (US) 2019-10-10 — — WO disclosed
CN-105873925-B Antiparasitic and insecticidal isoxazoline compounds 勃林格殷格翰动物保健美国公司 2019-09-10 — — CN disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 — — US disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 — — US disclosed
CN-101155789-A 1H-quinazoline-2, 4-diones and their use as AMPA-receptor ligands NOVARTIS AG (CH) 2008-04-02 — — CN disclosed
CN-1989113-A Quinazoline derivatives NOVARTIS AG (CH) 2007-06-27 — — CN disclosed
US-20060167324-A1 High-purity (fluoroalkyl)benzene derivative and process for producing the same MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2006-07-27 — — US disclosed
CN-1653029-A High-purity (fluoroalkyl) benzene derivative and preparation method thereof MITSUBISHI GAS CHEMICAL CO (JP) 2005-08-10 — — CN disclosed
EP-1500641-A1 HIGH-PURITY (FLUOROALKYL)BENZENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2005-01-26 — — EP disclosed
US-6642222-B2 Useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions ABBOTT LABORATORIES 2003-11-04 — — US disclosed
US-20030055035-A1 Pyrano piperidino and thiopyrano compounds and methods of use ABBOTT LABORATORIES 2003-03-20 — — US disclosed
EP-1278747-A1 PYRANO, PIPERIDINO, AND THIOPYRANO COMPOUNDS AND METHODS OF USE Abbott Laboratories (US) 2003-01-29 — — EP disclosed
WO-2001083484-A1 PYRANO, PIPERIDINO, AND THIOPYRANO COMPOUNDS AND METHODS OF USE ABBOTT LABORATORIES (US) 2001-11-08 — — WO disclosed
WO-1998011895-A1 A METHOD FOR THE PREVENTION OF MIGRAINE ELI LILLY AND COMPANY (US) 1998-03-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030055035-A1 Pyrano piperidino and thiopyrano compounds and methods of use KCNJ3, KCNJ6, KCNJ5 ALDH1A1 571/4885SRD5A2 2276/4885TP53 4788/4885
US-20250388604-A1 Compounds and Their Use as PDE4 Activators PDE4A, PDE7A, PDE4B ALDH1A1 989/4885SRD5A2 110/4885TP53 4753/4885
US-20060167324-A1 High-purity (fluoroalkyl)benzene derivative and process for producing the same HBB, AFF4, AFF2 ALDH1A1 669/4885SRD5A2 2791/4885TP53 1264/4885
US-20260022116-A1 IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF MAPK1, MAPK3, MAPK6 ALDH1A1 1232/4885SRD5A2 527/4885TP53 1184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.