Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.44 |
| ▸ | THRA | P10827 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.41 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.41 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073582 | 0.77 | THRB (0.46) | THRBTHRACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29935883 | 0.77 | KAT8 (0.46) | CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL1605185 | 0.77 | KAT8 (0.46) | CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL4305481 | 0.77 | KAT8 (0.46) | CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL23953303 | 0.76 | CYP1A2 (0.39) | CYP2C9CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL22869156 | 0.76 | BACE1 (0.36) | MEN1KMT2A | |
| SCHEMBL9734644 | 0.75 | SKP2 (0.50) | THRBTHRASKP2PLK1ALDH1A1 | |
| SCHEMBL23008847 | 0.75 | CYP3A4 (0.47) | THRBTHRACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25127087 | 0.74 | SKP2 (0.46) | THRBCYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL26936604 | 0.74 | THRA (0.51) | THRBTHRACYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006412-A2 | CONJUGATES OF AMPK INHIBITORS AND PROTAC DEGRADERS AND RELATED USES | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021003339-A1 | AMP-ACTIVATED PROTEIN KINASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-01-07 | — | — | WO | disclosed |