Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236184 | 0.90 | NPC1 (0.50) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL2213727 | 0.88 | NPC1 (0.48) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL13584911 | 0.88 | NPC1 (0.48) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL12231564 | 0.86 | ALDH1A1 (0.59) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL11635933 | 0.86 | NPC1 (0.47) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL11635257 | 0.84 | MAPT (0.57) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL14449056 | 0.84 | MEN1 (0.56) | NPC1ALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL14058841 | 0.83 | ALDH1A1 (0.46) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL11983715 | 0.83 | EPHX1 (0.49) | NPC1ALDH1A1MAPTKDM4ETSHR | |
| 4-Chlorophenylbiguanide SCHEMBL305068 | 0.83 | NPC1 (0.53) | NPC1ALDH1A1MAPTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201688-A1 | N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-08-18 | — | — | US | claimed |
| US-4507250-A | OXIDATION, SALT FORMATION | GESHURI LABORATORIES LTD. (IL) | 1985-03-26 | — | — | US | disclosed |
| US-4486356-A | BY-PRODUCT INHIBITION | GESHURI LABORATORIES, LTD. (IL) | 1984-12-04 | — | — | US | disclosed |
| EP-0125363-A1 | Process for producing N-phosphonomethylglycine acid | Geshuri Laboratories Ltd. (IL) | 1984-11-21 | — | — | EP | disclosed |
| EP-0098034-A2 | A process for producing n-phosphonomethylglycine derivatives and herbicidal compounds and compositions prepared thereby | Geshuri Laboratories Ltd. (IL) | 1984-01-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201688-A1 | N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS | SIGMAR1, TMEM97, HYOU1 | NPC1 1663/4885ALDH1A1 3426/4885MAPT 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.