Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 1/20 | 0.45 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14090180 | 0.69 | UBE2M (0.52) | UBE2MDCUN1D1SLC2A1HPGDMEN1 | |
| SCHEMBL1509453 | 0.69 | ALDH1A1 (0.55) | UBE2MDCUN1D1SLC2A1HPGDMEN1 | |
| SCHEMBL1509545 | 0.68 | UBE2M (0.51) | UBE2MDCUN1D1SLC2A1HPGDMEN1 | |
| SCHEMBL6403162 | 0.66 | POLB (0.54) | HPGDMEN1KMT2AMAPK1CYP1A2 | |
| SCHEMBL17824733 | 0.65 | ALDH1A1 (0.56) | HPGDMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL18657527 | 0.62 | UBE2M (1.00) | UBE2MDCUN1D1SLC2A1MEN1KMT2A | |
| SCHEMBL23077850 | 0.60 | UBE2M (0.61) | UBE2MDCUN1D1CYP3A4 | |
| SCHEMBL4204403 | 0.60 | EPHX2 (0.57) | MEN1KMT2AMAPK1CYP1A2NAMPT | |
| SCHEMBL2856089 | 0.59 | HPGD (1.00) | HPGDMEN1KMT2AMAPK1EED | |
| SCHEMBL14090174 | 0.59 | ALDH1A1 (0.47) | UBE2MDCUN1D1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007594-A1 | IRE1 ACTIVATING COMPOUNDS FOR USE IN THERAPY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-01-14 | — | — | WO | disclosed |
| US-20210008064-A1 | IRE1 ACTIVATING COMPOUNDS FOR USE IN THERAPY | THE SCRIPPS RESEARCH INSTITUTE | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210008064-A1 | IRE1 ACTIVATING COMPOUNDS FOR USE IN THERAPY | XBP1, ATF4, HSPA5 | UBE2M 3479/4885DCUN1D1 2690/4885SLC2A1 2363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.