Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | EED | O75530 | 1/20 | 0.64 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.64 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.64 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.64 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | FPR1 | P21462 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CCR1 | P32246 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854347 | 0.91 | HPGD (0.84) | HPGDNPC1RAB9ACCR1MEN1 | |
| SCHEMBL2854061 | 0.91 | HPGD (0.84) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2850617 | 0.91 | HPGD (0.84) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2857166 | 0.89 | HPGD (0.80) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2857896 | 0.87 | HPGD (0.77) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2605692 | 0.86 | HPGD (0.76) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2856450 | 0.86 | HPGD (0.74) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL2850143 | 0.85 | CCR1 (0.85) | HPGDNPC1RAB9APOLBCCR1 | |
| SCHEMBL2854119 | 0.85 | HPGD (0.73) | HPGDEEDRBBP4SUZ12EZH2 | |
| SCHEMBL10367090 | 0.84 | HPGD (0.72) | HPGDNPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | HPGD 1358/4885EED 3890/4885RBBP4 4038/4885 |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | FBL, HNRNPA1, HNRNPUL1 | HPGD 4613/4885EED 2518/4885RBBP4 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.