Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ME2 | P23368 | 1/20 | 0.52 |
| ▸ | ME1 | P48163 | 1/20 | 0.52 |
| ▸ | ME3 | Q16798 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874890 | 0.96 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1POLBME2ME1 | |
| SCHEMBL22875382 | 0.85 | L3MBTL1 (0.66) | SMN1; SMN2ALDH1A1POLBL3MBTL1HSD11B1 | |
| SCHEMBL20386535 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1POLBME2ME1 | |
| SCHEMBL22874685 | 0.84 | GPR119 (0.53) | POLBMEN1KMT2AL3MBTL1CYP3A4 | |
| SCHEMBL26331458 | 0.81 | L3MBTL1 (0.63) | SMN1; SMN2ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL14495101 | 0.81 | PKM (0.59) | SMN1; SMN2ALDH1A1POLBME2ME1 | |
| SCHEMBL14293643 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBME2ME1 | |
| SCHEMBL14115762 | 0.81 | POLB (0.61) | SMN1; SMN2ALDH1A1POLBME2ME1 | |
| SCHEMBL26330814 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1POLBME2ME1 | |
| SCHEMBL22874894 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1POLBME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | CRBN, IKZF1, IKZF3 | SMN1; SMN2 2474/4885ALDH1A1 3363/4885POLB 3436/4885 |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | CRBN, IKZF1, IKZF3 | SMN1; SMN2 2931/4885ALDH1A1 4009/4885POLB 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.