Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 12/20 | 0.51 |
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | SCN1A | P35498 | 3/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12417395 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL2287687 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL13366991 | 0.95 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL12377940 | 0.94 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL12415060 | 0.94 | MAPT (0.61) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL12415064 | 0.94 | MAPT (0.58) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL12415063 | 0.93 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL10120103 | 0.93 | MAPT (0.64) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL12414672 | 0.93 | TP53 (0.55) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL12415061 | 0.90 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200308539-A1 | AFFINITY-TAGGED PHOTOSWITCHES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-01 | — | — | US | disclosed |
| US-9688617-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688617-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160229794-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-08-11 | — | — | US | disclosed |
| US-9334231-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334231-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-8993736-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | ENERGY, UNITED STATES DEPARTMENT OF | 2011-08-25 | — | — | US | disclosed |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | ENERGY, UNITED STATES DEPARTMENT OF | 2011-08-25 | — | — | US | disclosed |
| WO-2010051343-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2010051343-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | PPP1R10, PPP6R1, PPP6R3 | ALDH1A1 4830/4885LMNA 4385/4885MAPT 4166/4885 |
| US-20160229794-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | PPP1R10, PPP6R1, PPP6R3 | ALDH1A1 4830/4885LMNA 4385/4885MAPT 4166/4885 |
| US-20200308539-A1 | AFFINITY-TAGGED PHOTOSWITCHES AND METHODS OF USE THEREOF | CD2BP2, AGBL2, CLTB | ALDH1A1 4367/4885LMNA 4187/4885MAPT 3741/4885 |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | PPP1R10, PPP6R1, PPP6R3 | ALDH1A1 4830/4885LMNA 4385/4885MAPT 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.