SCHEMBL2289162

SCHEMBL2289162

COc1c[c]cc(Cl)c1C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.34
NPC1 O15118 1/20 0.34
MAPT P10636 3/20 0.32
MAPK1 P28482 3/20 0.32
NPSR1 Q6W5P4 3/20 0.32
ALDH1A1 P00352 2/20 0.32
HSP90AA1 P07900 2/20 0.32
RAB9A P51151 2/20 0.32
CACNA1B Q00975 2/20 0.32
APBA1 Q02410 2/20 0.32
APOBEC3G Q9HC16 2/20 0.32
PKM P14618 1/20 0.32
CCR6 P51684 1/20 0.32
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
POLB P06746 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
ALOX12 P18054 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL312352 0.83 CA12 (0.36) GAAMAPTALDH1A1PKMMEN1
SCHEMBL2282004 0.79 GAA (0.35) GAANPC1MAPTMAPK1NPSR1
SCHEMBL943527 0.77 ALDH1A1 (0.37) GAANPC1MAPTMAPK1NPSR1
SCHEMBL1005079 0.77
SCHEMBL20743927 0.77 MAPT (0.38) GAAMAPTALDH1A1RAB9APKM
SCHEMBL2287683 0.76 ACHE (0.32) ACHE
SCHEMBL2288168 0.76 GAA (0.33) GAANPC1NPSR1ALDH1A1MEN1
SCHEMBL1205334 0.76 KMT2A (0.38) GAANPC1MAPTMAPK1NPSR1
SCHEMBL2284993 0.76 GAA (0.38) GAANPC1MAPTMAPK1NPSR1
SCHEMBL499678 0.75 CA12 (0.35) GAANPC1MAPTMAPK1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7989394-B2 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane compounds BASF SE (DE) 2011-08-02 US disclosed
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds BASF SE (DE) 2009-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds AAAS, AIPL1, ATXN2 GAA 3610/4885NPC1 1526/4885MAPT 4268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.