Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22892259 | 0.90 | LMNA (0.59) | TSHRMAPK1HTTALDH1A1NPSR1 | |
| SCHEMBL19002655 | 0.85 | MAPT (0.68) | TSHRMAPK1ALDH1A1GAALMNA | |
| SCHEMBL12781995 | 0.85 | TSHR (0.70) | TSHRMAPK1HTTALDH1A1NPSR1 | |
| SCHEMBL19002661 | 0.84 | L3MBTL1 (0.58) | TSHRMAPK1ALDH1A1MAPTPKM | |
| SCHEMBL22892248 | 0.84 | TSHR (0.50) | TSHRMAPK1HTTALDH1A1NPSR1 | |
| SCHEMBL17306127 | 0.83 | MAPT (0.53) | TSHRALDH1A1LMNAMAPTPOLB | |
| SCHEMBL22892378 | 0.83 | MAPT (0.49) | TSHRMAPK1HTTALDH1A1NPSR1 | |
| SCHEMBL12781882 | 0.81 | TSHR (0.73) | TSHRMAPK1ALDH1A1LMNAPOLB | |
| SCHEMBL31651670 | 0.81 | DRD2 (0.54) | MAPK1HTTNPSR1GAALMNA | |
| SCHEMBL22892255 | 0.81 | TSHR (0.53) | TSHRMAPK1HTTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468955-B1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-01-06 | — | — | EP | disclosed |