Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22892248 | 0.91 | TSHR (0.50) | TSHRMEN1KMT2AMAPTRECQL | |
| SCHEMBL22892378 | 0.90 | MAPT (0.49) | TSHRMEN1KMT2AMAPTRECQL | |
| SCHEMBL22892383 | 0.87 | MEN1 (0.47) | TSHRMEN1KMT2AMAPTRECQL | |
| SCHEMBL22892269 | 0.85 | TSHR (0.56) | TSHRMEN1KMT2AMAPTRECQL | |
| SCHEMBL22892259 | 0.81 | LMNA (0.59) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL22892249 | 0.81 | TSHR (0.62) | TSHRMEN1KMT2AMAPTRECQL | |
| SCHEMBL22062951 | 0.78 | ADAM17 (0.63) | TSHRMEN1KMT2AALDH1A1ADAMTS5 | |
| SCHEMBL19691523 | 0.77 | ADAMTS5 (0.76) | ADAMTS5 | |
| SCHEMBL22892230 | 0.77 | MEN1 (0.56) | TSHRMEN1KMT2AMAPTRECQL | |
| SCHEMBL19002655 | 0.76 | MAPT (0.68) | TSHRMEN1KMT2AMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468955-B1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-01-06 | — | — | EP | disclosed |