Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 5/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22896355 | 0.95 | L3MBTL1 (0.56) | SMN1; SMN2MAPK1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL30133620 | 0.95 | L3MBTL1 (0.56) | SMN1; SMN2MAPK1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL22897262 | 0.90 | ALDH1A1 (0.60) | SMN1; SMN2MAPK1ALDH1A1KMT2AKDM4E | |
| SCHEMBL22897259 | 0.86 | L3MBTL1 (0.48) | ALDH1A1KMT2AL3MBTL1GAAMEN1 | |
| SCHEMBL22896801 | 0.85 | CAPN1 (0.48) | ALDH1A1KMT2AL3MBTL1GAAMEN1 | |
| SCHEMBL22897186 | 0.85 | CAPN1 (0.51) | CAPN1 | |
| SCHEMBL22897206 | 0.84 | HPGDS (0.50) | SMN1; SMN2MAPK1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL22897249 | 0.84 | CAPN1 (0.48) | L3MBTL1CAPN1 | |
| SCHEMBL22897164 | 0.83 | CAPN1 (0.50) | CAPN1 | |
| SCHEMBL22896988 | 0.83 | CAPN1 (0.50) | CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | SMN1; SMN2 200/4885MAPK1 3457/4885ALDH1A1 4193/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | SMN1; SMN2 263/4885MAPK1 3624/4885ALDH1A1 4421/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | SMN1; SMN2 200/4885MAPK1 3457/4885ALDH1A1 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.