Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.45 |
| ▸ | CCR2 | P41597 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12766638 | 0.80 | GAA (0.53) | USP2POLBKMT2AMEN1GAA | |
| SCHEMBL6778457 | 0.71 | TDP1 (0.47) | USP2HSD17B10TP53RXFP1KMT2A | |
| SCHEMBL29005804 | 0.68 | POLB (0.57) | USP2POLBHSD17B10TP53GAA | |
| SCHEMBL22900276 | 0.66 | NMT1 (0.41) | USP2POLBKDM1AKDM1BNPSR1 | |
| SCHEMBL29820628 | 0.64 | DGAT1 (0.66) | KMT2AGAAALDH1A1DGAT1 | |
| SCHEMBL8204 | 0.64 | DGAT1 (0.66) | KMT2AGAAALDH1A1DGAT1 | |
| SCHEMBL22778088 | 0.63 | KDM1A (0.56) | KDM1AKDM1BKMT2AMEN1NPSR1 | |
| SCHEMBL30021045 | 0.63 | KDM1A (0.56) | KDM1AKDM1BKMT2AMEN1NPSR1 | |
| SCHEMBL20177644 | 0.62 | KDM1A (0.47) | KDM1AKDM1BKMT2AMEN1DGAT1 | |
| SCHEMBL5940620 | 0.62 | KDM1A (0.43) | KDM1AKDM1BKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |