Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25459039 | 1.00 | PARP1 (0.53) | PARP1CXCR4KDM1AGRIN2BHDAC1 | |
| SCHEMBL22904326 | 1.00 | PARP1 (0.53) | PARP1CXCR4KDM1AGRIN2BHDAC1 | |
| SCHEMBL20483030 | 0.97 | PARP1 (0.49) | PARP1CXCR4KDM1AGRIN2BHDAC1 | |
| SCHEMBL30069451 | 0.97 | PARP1 (0.49) | PARP1CXCR4KDM1AGRIN2BHDAC1 | |
| SCHEMBL20483031 | 0.97 | PARP1 (0.49) | PARP1CXCR4KDM1AGRIN2BHDAC1 | |
| SCHEMBL26338460 | 0.89 | PARP1 (0.52) | PARP1CXCR4KDM1AGRIN2BFNTA | |
| SCHEMBL20482778 | 0.88 | FNTA (0.47) | PARP1CXCR4KDM1AHDAC1HDAC6 | |
| SCHEMBL20482781 | 0.88 | FNTA (0.47) | PARP1CXCR4KDM1AHDAC1HDAC6 | |
| SCHEMBL26338770 | 0.86 | PARP1 (0.47) | PARP1CXCR4GRIN2BFNTAFNTB | |
| SCHEMBL25459112 | 0.81 | AGTR2 (0.46) | PARP1CXCR4KDM1AGRIN2BHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12286434-B2 | Pan-tropic entry inhibitors | EMORY UNIVERSITY (US) | 2025-04-29 | — | — | US | disclosed |
| US-20230271961-A1 | Pan-Tropic Entry Inhibitors | UNIV EMORY (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230271961-A1 | Pan-Tropic Entry Inhibitors | UNIV EMORY (US) | 2023-08-31 | — | — | US | disclosed |
| US-11649235-B2 | Pan-tropic entry inhibitors | EMORY UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-11649235-B2 | Pan-tropic entry inhibitors | EMORY UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-11649235-B2 | Pan-tropic entry inhibitors | EMORY UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-20210017178-A1 | Pan-Tropic Entry nhibitors | UNIV EMORY (US) | 2021-01-21 | — | — | US | disclosed |
| US-20160331734-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. | 2016-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649235-B2 | Pan-tropic entry inhibitors | CXCR4, CCR5, CXCL12 | PARP1 630/4885CXCR4 1/4885KDM1A 4662/4885 |
| US-20210017178-A1 | Pan-Tropic Entry nhibitors | CXCR4, CXCL12, CCR5 | PARP1 473/4885CXCR4 1/4885KDM1A 4225/4885 |
| US-20230271961-A1 | Pan-Tropic Entry Inhibitors | CXCR4, CCR5, CXCL12 | PARP1 555/4885CXCR4 1/4885KDM1A 4439/4885 |
| US-20160331734-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | PARP1 1054/4885CXCR4 1003/4885KDM1A 629/4885 |
| US-12286434-B2 | Pan-tropic entry inhibitors | CXCR4, CCR5, CXCL12 | PARP1 630/4885CXCR4 1/4885KDM1A 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.